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Figure 2 E-Cigarette (2.4% Nicotine) Modulates the PARP1/SIRT1 Axis PARP-1 activation and consequent NAD+ decrease are a well-established signaling pathway that mediates hepatic cell death and metabolic changes associated with DNA damage ( In prior studies using e-cigarettes, we observed hepatic steatosis (Figures 1, 2, we also found that e-cigarette (0%)-treated mice were similar to saline-treated mice

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